With Zane Kirchner moving to the right wing from full back, Dave Kearney moves to the bench with brother Rob taking the number 15 jersey from the South African.
Luke Fitzgerald, who is due to win his 120th cap on Saturday, continues his fine run of form on the left wing.
With 402 Leinster caps between them, back in to the centre come the experienced duo of Gordon D'Arcy and Brian O'Driscoll. Eoin Reddan starts at scrumhalf against his former club, with Ian Madigan beside him at outhalf.
The pack also sees a number of fresh faces from last weekend plus a positional switch in the back row. Man of the Match from the Ulster game, Jordi Murphy is selected at flanker, with captain Jamie Heaslip returning at 8. Rhys Ruddock is once again selected at 6.
Former Connacht hooker Sean Cronin, who spent three years at the Sportsground before joining Leinster, is also selected to start against his former club. Joining him in the front row will be Martin Moore and Jack McGrath, who earned his 50th cap off the bench against Ulster.
Finally in the second row Devin Toner and Tom Denton start in place of Leo Cullen and Mike McCarthy. McCarthy is however named amongst the replacements.
LEINSTER:
15: Rob Kearney
14: Zane Kirchner
13: Brian O'Driscoll
12: Gordon D'Arcy
11: Luke Fitzgerald
10: Ian Madigan
9: Eoin Reddan
1: Jack McGrath
2: Sean Cronin
3: Martin Moore
4: Devin Toner
5: Tom Denton
6: Rhys Ruddock
7: Jordi Murphy
8: Jamie Heaslip CAPTAIN
REPLACEMENTS:
16: Aaron Dundon
17: Jack O'Connell
18: Mike Ross
19: Mike McCarthy
20: Dominic Ryan
21: Isaac Boss
22: Jimmy Gopperth
23: Dave Kearney
REFEREE: George Clancy (IRFU), ASSISTANT REFEREES: Leo Colgan, Ollie Hodges (both IRFU) CITING COMMISSIONER: Denis Templeton (IRFU) TMO: Jude Quinn (IRFU)