And victory against Gloucester - a side they beat 26-10 in the reverse fixture - would go a long way to seeing the Munstermen book themselves a spot in the quarter-finals.
But while Gloucester might be struggling the in the English Premiership this season, Penney is urging his side to take nothing for granted, particularly with their hosts keen to set the record straight after being thumped by Saracens 29-8 last time out.
"They'll be very motivated to do well, there's nothing worse in some respects than going to an area with a proud history, like Gloucester have at Kingsholm, after they've been wounded badly, as they were last week against Saracens," he said.
"They have been criticised roundly by their supporters, their public and their ex-players which is pretty hard to take.
"They'll be desperate to do well on Saturday which makes our job that little bit harder.
"It's a challenging place to go and on the back of what happened last week that makes it even more challenging."
Follow us on Facebook, join the conversation on Twitter, sign up to our YouTube channel for extensive match highlights and sign up to our newsletter for regular updates on the RaboDirect PRO12
63x46.png){kind=logo}