Antonio Pavanello and his teammates, moreover, have to recover quickly from last Saturday's bitter loss against Ulster.
Referee for the match will be Irish Mr. Alain Rolland and will be broadcast at 22:45 (Italian time) on Rai Sport 2.
Franco Smith, compared to last Saturday, has not made the front five and their replacements - with the only exception being Franco Sbaraglini, who didn't play against Ulster as he had a temperature.
In the back row, injured Robert Barbieri is replaced by Francesco Minto, and Marco Filippucci is starting from the bench.
The major changes are among the backs. Tommaso Iannone is starting as outside centre, with Alberto Sgarbi as inside centre.
Brendan Williams is to rest, Kristopher Burton is thus playing as fullback, Luke McLean is starting from the bench and Alberto Di Bernardo is at fly-half with scrum-half Edoardo Gori.
Wingers for the match are Ludovico Nitoglia on the left, and Tommaso Benvenuti on the right.
Starting line-up:
15 Kristopher Burton
14 Tommaso Benvenuti
13 Tommaso Iannone
12 Alberto Sgarbi
11 Ludovico Nitoglia
10 Alberto Di Bernardo
9 Edoardo Gori
8 Manoa Vosawai
7 Alessandro Zanni
6 Francesco Minto
5 Corniel Van Zyl
4 Antonio Pavanello (captain)
3 Lorenzo Cittadini
2 Enrico Ceccato
1 Michele Rizzo
On the bench:
16 Franco Sbaraglini
17 Matteo Muccignat
18 Ignacio Fernandez Rouyet
19 Valerio Bernabò
20 Gonzalo Padrò
21 Marco Filippucci
22 Fabio Semenzato
23 Luke McLean
Head Coach: Franco Smith.
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