The changes are completed by returning Scotland internationalists Ross Ford (hooker) and Geoff Cross (prop) who start in place of James Hilterbrand and Willem Nel.
They'll be joined on the bench by scrum-half Sean Kennedy, who has returned from his loan spell at London Irish to replace the injured Sam Hidalgo-Clyne (shoulder), while Ben Atiga and Joaquin Dominguez take the places vacated by Leonard and Beard.
Edinburgh Rugby head coach, Alan Solomons, said: "We've been able to pick a pretty strong pack and we know that the Ospreys too have a powerful set of forwards, so we're looking forward to meeting that challenge.
"In addition to Greig [Laidlaw] who's with the national team, we have three very good Scottish scrum-halves in Grayson [Hart], Sean [Kennedy] and Sammy [Hidalgo-Clyne].
"We took advantage of the opportunity to loan Sean out to complete his recovery from a knee injury and get some game time. He's returned looking nice and sharp so it's great to have him back in the fray."
Keen to respark the eigth-placed club's climb up the table, Solomons added: "This is an important game for us because these players have had a couple of games together as a group. We are now looking for a good performance on this third time out.
"It's important for the club, particularly as we're playing at home, to deliver a good performance that will give us the opportunity to get the result."
Edinburgh Rugby team to play Ospreys at Meggetland on Friday 28 February live on BBC ALBA
15 Carl Bezuidenhout
14 Dougie Fife
13 Sam Beard
12 Andries Strauss
11 Jack Cuthbert
10 Harry Leonard
9 Grayson Hart
1 Wicus Blaauw
2 Ross Ford
3 Geoff Cross
4 Grant Gilchrist
5 Izak van der Westhuizen
6 Mike Coman CAPTAIN
7 Roddy Grant
8 Cornell Du Preez
Substitutes
16 James Hilterbrand
17 Alex Allan
18 Willem Nel
19 Ollie Atkins
20 Tomas Leonardi
21 Sean Kennedy
22 Ben Atiga
23 Joaquin Dominguez
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