Leinster are currently riding high with eight straight wins in all competitions while they are unbeaten at the RDS since the end of March last year.
Zebre meanwhile, arrive in Dublin on a high having achieved their third victory of the season in their last contest at home to Cardiff Blues.
Also on Friday, Ulster will be looking to pick up from where they left off last time out, having seen off the Scarlets last Friday in the only match of the weekend.
They travel to Edinburgh where they will face former Ulster coach Alan Solomons, who has led his side to four wins in their last five RaboDirect PRO12 outings.
Friday's action gets underway with an all-Welsh affair as the Ospreys - the only non-Irish side currently in the top four - host Cardiff Blues.
The Ospreys have won only one of their last four however the Blues will begin life without Phil Davies, having parted company with their director of rugby following the defeat to Zebre.
On Saturday, Munster will look to get back to winning ways after defeat to the Scarlets last time out but they host Treviso at Thomond Park as the only remaining RaboDirect PRO12 side with a 100 per cent home winning record.
Meanwhile, it what promises to be a tight affair, the Scarlets head to Glasgow Warriors looking to keep their top-four ambitions alive as fifth host sixth.
The last eight of the Warriors' matches in all competitions has seen the losing side collect a bonus point while the Scarlets have prevailed in two of their last three trips to Glasgow.
And completing the action this weekend, Connacht will be bidding for a fourth straight RaboDirect PRO12 victory away to Newport Gwent Dragons.
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