Luke McLean is playing fullback, while Fabio Semenzato and the hero of the latest match Alberto Di Bernardo are playing scrum-half and fly-half respectively.
Simone Favaro, who was down with the flu last week, is back as flanker.
Captain Antonio Pavanello is playing lock with Francesco Minto, while the front row will remain unchanged.
On the bench are returning Enrico Ceccato, Alberto De Marchi and Giulio Toniolatti.
Starting line-up:
15 Luke McLean
14 Tommaso Iannone
13 Tommaso Benvenuti
12 Alberto Sgarbi
11 Tobias Botes
10 Alberto Di Bernardo
9 Fabio Semenzato
8 Robert Barbieri
7 Alessandro Zanni
6 Simone Favaro
5 Francesco Minto
4 Antonio Pavanello (captain)
3 Lorenzo Cittadini
2 Leonardo Ghiraldini
1 Michele Rizzo
Replacements:
16 Enrico Ceccato
17 Alberto De Marchi
18 Pedro Di Santo
19 Valerio Bernabò
20 Dean Budd
21 Paul Derbyshire
22 Kristopher Burton
23 Giulio Toniolatti
Head Coach: Franco Smith.