Following last weekend's 33-12 win at Cardiff Blues, Tommy Seymour continues on the right wing and Canadian winger DTH van der Merwe comes in for try-scorer Sean Lamont.
Alex Dunbar moves to No.13, with Peter Horne switching from fly-half to inside centre.
Scotland stand-off Duncan Weir comes into the starting line-up and Niko Matawalu replaces Henry Pyrgos at scrum-half, after his two tries from the bench last weekend.
It's an all-new front-row with Gordon Reid coming in for Alex Allan at loose-head, Kevin Bryce replacing Pat MacArthur at hooker and Euan Murray named at tight-head in place of Rossouw de Klerk. Allan and de Klerk are named amongst the replacements.
Tim Swinson continues in the engine room, with Fijian second-row Leone Nakarawa replacing the injured Jonny Gray.
The only change in the back-row sees Tyrone Holmes coming in for Chris Fusaro at open-side. Rob Harley continues on the blind-side and Josh Strauss once again captains the side from Number 8.
The Warriors have decided to go with six forwards and two backs on the bench, with winger Lee Jones also added to the squad.
Glasgow Warriors head coach Gregor Townsend said: "We've had two good wins this season, but we know we'll have to put in a better performance tomorrow, if we're to keep the momentum going.
"The Dragons are a physical side, both in how they are set up defensively and also their desire to contest at ruck time. They also have some very good ball carriers throughout their side.
"They were unlucky not to win both of their opening games, which were very close and we are well aware that we lost to them home and away last season, so it is a tough challenge that awaits us at Rodney Parade."
Glasgow Warriors team to play Newport Gwent Dragons, Rodney Parade, Saturday 20 September (kick-off 2.40pm) - live on Sky Sports 1:
15. Stuart Hogg
14. Tommy Seymour
13. Alex Dunbar
12. Peter Horne
11. DTH van der Merwe
10. Duncan Weir
9. Niko Matawalu
1. Gordon Reid
2. Kevin Bryce
3. Euan Murray
4. Tim Swinson
5. Leone Nakarawa
6. Rob Harley
7. Tyrone Holmes
8. Josh Strauss (Captain)
Replacements
16. Fraser Brown
17. Alex Allan
18. Rossouw de Klerk
19. James Eddie
20. Chris Fusaro
21. Adam Ashe
22. Henry Pyrgos
23. Lee Jones
Not available due to injury: Mike Cusack (medical / illness), Ryan Grant (shoulder), Jonny Gray (chest / ribs), Dougie Hall (arm), Sean Lamont (foot), Pat MacArthur (head), Sean Maitland (ankle), Finn Russell (shoulder), Richie Vernon (achilles), Jon Welsh (shoulder) and Ryan Wilson (shoulder).
Guinness PRO12
Suite 208, Alexandra House,
The Sweepstakes
Ballsbridge, Dublin 4, Ireland