The international fullback has returned to full fitness after suffering a back strain before the Welsh Derby, resulting in him not appearing for the Dragons against the Scarlets in Round 5.
Alongside Byrne, Lyn Jones has made seven changes to the team that faced the Scarlets last weekend.
The fullback is joined in the back three by Matthew Pewtner and Hallam Amos. The centre pairing takes on the form of Tom Prydie and Ashley Smith while both half-backs, Jason Tovey and Jonathan Evans, get the nod and retain their places.
One change has been made to the front row alongside Boris Stankovich and Dan Way, as Elliot Dee replaces hooker T. Rhys Thomas who moves to the bench. The second row also has one change as Andrew Coombs, who returns from a three week ban, replaces Ian Gough. The back row has one change and one positional change made to it as Lewis Evans and Nic Cudd pull on the flanker jerseys and Andy Powell is named as number 8.
Director of rugby Lyn Jones, has made three changes to the replacements bench as Hugh Gustasfon, Lloyd Fairbrother, James Thomas, Richie Rees and Angus O'Brien are joined by T. Rhys Thomas, Ian Gough, and Aled Brew.
Newport Gwent Dragons team to face Edinburgh
Lee Byrne (c), Matthew Pewtner, Tom Prydie, Ashley Smith, Hallam Amos, Jason Tovey, Jonathan Evans; Boris Stankovich, Elliot Dee, Dan Way, Andrew Coombs, Rynard Landman, Lewis Evans, Nic Cudd, Andy Powell.
Replacements:
T. Rhys Thomas, Hugh Gustafson, Lloyd Fairbrother, Ian Gough, James Thomas, Richie Rees, Angus O'Brien, Aled Brew.
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