Michael Allen is named on the left wing and replaces Craig Gilroy who is rested for the match.
Andrew Warwick, who signed his first senior contract with the province this week, starts at loosehead with Callum Black selected on the bench.
Ireland centre, Stuart Olding, has recovered from injury and is named on the bench. Sean Reidy and Peter Nelson are also selected as replacements.
Ulster are fourth in the Guinness PRO12, level on points with Ospreys and a point behind leaders Munster.
The province's next home match is against Connacht on Boxing Day. There is limited availability for the game. Tickets are available via Ticketmaster or the Ulster Rugby website.
The game is live on Sky Sports and on BBC Radio Ulster.
Ulster XV & Replacements to play Ospreys, Guinness PRO12, Liberty Stadium, Saturday 20th December, kick off 17:15 (15-9): L Ludik; T Bowe, D Cave, L Marshall, M Allen, I Humphreys, R Pienaar; (1-8): A Warwick, R Best (Capt), D Fitzpatrick, D Tuohy, F vd Merwe, R Diack, C Ross, R Wilson;
Replacements (16-23): R Herring, C Black, B Ross, A O'Connor, S Reidy, P Marshall, S Olding, P Nelson.
Guinness PRO12
Suite 208, Alexandra House,
The Sweepstakes
Ballsbridge, Dublin 4, Ireland