After being released by Leinster, the fly-half spent three successful seasons at Connacht, leading the Galway side to their first victory over Munster since 1986 with an historic 12-6 triumph in December 2008.
Since joining Munster in 2011, the 27-year-old has become a vital part of Anthony Foley's side and is hoping to secure back-to-back derby victories after inspiring his side to a 28-13 win against Leinster last weekend.
And while Pat Lam's side may be unbeaten in all competitions at the Sportsground this season, Keatley is confident Munster can prevent Connacht from continuing that record in 2015 as soon as New Year's Day.
"I'm looking forward to going back to where it all really started for me", Keatley told the Irish Examiner.
"They haven't been beaten at the Sportsground this year. These inter-provincial matches are huge, not just for Connacht, but massive for us as well and also for Leinster and Ulster.
"They give you the chance to go against people who are vying for your place with Ireland, a lot of bragging rights up for grabs and more importantly, four points up for grabs.
"Connacht do step things up against Munster of all teams. I was playing the last time they beat Munster - there weren't any tries and I kicked four penalties in a 12-6 result. I know what it means to them but I also know what it means to Munster to take on Connacht in the Sportsground.
"I remember when I was there, Connacht were talking about building a legacy. They have really stepped it up this year, unbeaten at home in the league is a great record, and goes to show how strong they are."
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