The 21-year-old Scotland international, who signed a new two-year deal with the Warriors earlier this month, has recovered from an injury sustained playing for Scotland in the viagogo Autumn Tests last November and makes his first appearance for the Warriors since the win over Montpellier in France last October.
Connor Braid, Murray McConnell and Will Bordill will make their first starts for the club, while Alex Toolis and Tommy Spinks are also in line to make their debuts from the bench, along with D'arcy Rae, who has returned from his loan spell with Benetton Treviso for this game.
Peter Murchie continues at full-back, with Niko Matawalu and DTH van der Merwe on either wing, while Richie Vernon and Fraser Lyle continue their centre partnership.
Braid starts his first game for the club at stand-off following confirmation that he will be staying at Scotstoun until the end of the season, while McConnell is handed his first start for the Warriors at scrum-half. It will be the 22-year-old's fifth appearance for the club.
In the forwards Alex Allan comes in at loose-head and after his try last weekend in the win over Ospreys Pat MacArthur is retained at hooker, with Rossouw de Klerk continuing at tight-head.
James Eddie moves from the back-row into the engine room in place of the suspended Leone Nakarawa and he'll partner captain Al Kellock.
In the back-row Ashe starts on the blind-side, Bordill comes in for the injured Tyrone Holmes at open-side and Josh Strauss continues at Number 8.
Winger Lee Jones is included amongst the replacements after recovering from an ankle injury, sustained in the win over Zebre earlier this month.
Glasgow Warriors head coach Gregor Townsend said: "After last weekend's win over Ospreys we now face another of the in-form teams in the GUINNESS PRO12 and we've had some massive games with Munster over the last couple of seasons.
"They are sitting second in the league, just four points behind us, so we're well aware of the importance of this game.
"A number of players could make their debuts for the club this weekend, which is a big opportunity for them to show what they can do and we're also delighted to welcome Adam (Ashe) back into our squad."
Glasgow Warriors team to play Munster, GUINNESS PRO12, Irish Independent Park, Saturday 28 February (kick-off 7.15pm) - live on Sky Sports 3:
15. Peter Murchie
14. Niko Matawalu
13. Richie Vernon
12. Fraser Lyle
11. DTH van der Merwe
10. Connor Braid
9. Murray McConnell
1. Alex Allan
2. Pat MacArthur
3. Rossouw de Klerk
4. James Eddie
5. Al Kellock (Captain)
6. Adam Ashe
7. Will Bordill
8. Josh Strauss
Replacements
16. Dougie Hall
17. Jerry Yanuyanutawa
18. D'arcy Rae
19. Alex Toolis
20. Tommy Spinks
21. Glenn Bryce
22. Lee Jones
23. Rory Hughes
Not available due to injury: Mike Cusack (foot), Chris Fusaro (ankle), Tyrone Holmes (knee), Sean Maitland (shoulder), Henry Pyrgos (knee), Gordon Reid (knee), Duncan Weir (arm) and Jon Welsh (hand).
Guinness PRO12
Suite 208, Alexandra House,
The Sweepstakes
Ballsbridge, Dublin 4, Ireland