Up front, Academy lock Ultan Dillane, who will be promoted to the senior squad next season, has been called in to partner Aly Muldowney in the second row.
Galway man Eoin McKeon is recalled to the back row to join captain John Muldoon and recent Player of the Month winner Eoghan Masterson.
From the replacements bench, Sportsground favourite George Naoupu is in line to make his 100th appearance in a Connacht shirt.
Commenting on the upcoming game, Pat Lam said:
"You could say this is our toughest game of the season with who we are up against and what is on the line. We understand the massive importance of tomorrow but we have prepared like we would every game. It's up to us to go out and perform as a team.
"Glasgow are the league leaders for a reason. They are a well-coached side with huge depth in their squad of internationals and they are the number one offloading team who can score plenty of tries. So defensively, we will have to be spot on.
"It's a huge challenge but we're really excited by it and the fact that we're at home makes it even more special. The Connacht support has been huge all year. They have carried us home in these big games before and with so much riding on the game, it's great to know that they'll be behind us again tomorrow."
Connacht team to face Glasgow Warriors
15. Tiernan O'Halloran
14. Danie Poolman
13. Robbie Henshaw
12. Bundee Aki
11. Matt Healy
10. Jack Carty
9. Kieran Marmion
1. Denis Buckley
2. Tom McCartney
3. Rodney Ah You
4. Ultan Dillane
5. Aly Muldowney
6. John Muldoon (captain)
7. Eoghan Masterson
8. Eoin McKeon
Replacements:
16. Shane Delahunt
17. Ronan Loughney
18. Finlay Bealham
19. Andrew Browne
20. George Naoupu
21. John Cooney
22. Miah Nikora
23. Darragh Leader
Unavailable/Injured: Jason Harris-Wright, Sean Henry, Nathan White, Michael Swift, Mick Kearney, Quinn Roux, Mata Fifita, Willie Faloon, Jake Heenan, Craig Ronaldson, Conor Finn, Dave McSharry, Mils Muliaina.
Connacht v Glasgow Warriors
Saturday 25th April
The Sportsground
Kick off 13:05
Tickets for Connacht v Glasgow are available online from tickets.ie, from Centra & SuperValu stores province-wide or from the Connacht Rugby ticket office located at the Sportsground (Mon - Fri 9am - 5pm).
Come early and enjoy the Family Fun Zone at the Sportsground before the match.
There will be lots of Family fun to be had with activities lined up such as:
Tackle cage, Speed cage, Target cage, Reaction challenge, 10-meter agility sprint and face painting.
There will even be some prizes and goodies for the kids that get involved!