Ospreys have the opportunity to restore their title as the most decorated side in the competition's history, after back-to-back titles for Leinster in the last two years drew them level with the Welsh region on four.
Glasgow Warriors contested their first PRO12 final last year, where they lost to Leinster at the RDS, and Gregor Townsend's men are itching to go one better this time around.
And as for the Irish contingent, Ulster are chasing a first title since 2006, while Munster could clinch their third PRO12 crown in the last seven seasons.
In an intriguing round of fixtures this weekend, those four will go head-to-head in a top-of-the-table double header.
With home semi-finals on offer to the top two the stakes could hardly be higher as we countdown to the GUINNESS PRO12 Final.
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