Last year's losing finalists host an Ulster side that have even more incentive to reach the showpiece event, as it will be hosted at their home - the Kingspan Stadium - on May 30.
Ulster will receive a second bite of the cherry after last week's defeat at Scotstoun, where Glasgow have not lost all season - make sure you're there on Friday night to see if Gregor Townsend's men can do the double.
The Ospreys must also find success at a fortress on Saturday, as they head to Thomond Park to take on the might of perennial challengers Munster.
Munster have not hosted a play-off since at Thomond Park since 2011 and enter the clash on a five-game GUINNESS PRO12 unbeaten run, but the Ospreys can hardly be discounted after racking up six league wins in a row themselves.
Indeed the last time Steve Tandy's troops ventured to Limerick they came away with a 19-14 win before going on to complete the double over the Munstermen this season.
Can the Ospreys make the third time count? Click here to snap up your ticket for the Saturday showdown.
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