Dave Kilcoyne and Stephen Archer both return to join Eusebio Guinazu in the front row, while O'Mahony's start at 6 see's Donnacha Ryan revert to the second row to partner Paul O'Connell with Paddy Butler and CJ Stander remaining at 7 and 8.
Last weekend's Man of the Match Conor Murray continues at half back alongside Ian Keatley, as do Denis Hurley and Andrew Smith in the centre, while the final change sees Simon Zebo re-join Keith Earls and Felix Jones in the back three.
From the bench, Duncan Casey could make his return to action after recovering from a back injury while BJ Botha draws ever closer to the century mark and could make his 99th appearance for the province this weekend.
Munster: Felix Jones; Keith Earls, Andrew Smith, Denis Hurley, Simon Zebo; Ian Keatley, Conor Murray; Dave Kilcoyne, Eusebio Guinazu, Stephen Archer; Donnacha Ryan, Paul O'Connell; Peter O'Mahony Capt., Paddy Butler, CJ Stander.
Replacements: Duncan Casey, John Ryan, BJ Botha, Billy Holland, Jack O'Donoghue, Duncan Williams, JJ Hanrahan, Ronan O'Mahony.
Ticket Update
Close to 15000 tickets have been sold since last Saturday evening and tickets will continue to be available via Ticketmaster.ie and from the Munster Rugby ticket offices in Irish Independent Park and Thomond Park Stadium.
On match-day tickets will be available on sale from 9am from the stadium.
Tickets are from just €20 for Adults with Family Terrace Packs available from just €40.
Group Special Offer: 20 Junior tickets & 5 Adult tickets just €100.
Should local youth groups, club or school, etc be interested in availing of this offer, please contact the Munster Rugby Ticket Office on 061-421103 or email tickets@munsterrugby.ie