Fergus McFadden is named in an exciting back three alongside Andrew Conway and Isa Nacewa.
Leo Cullen leads the team and partners Damian Browne at second row.
In addition there are home debuts for Ireland tight-head prop Michael Bent - who is named in the front row alongside returning internationals Sean Cronin and South Africa's Heinke van der Merwe - and centre Andrew Goodman, who has featured in the province's last two away league games.
The likes of Cian Healy, Mike Ross and Isaac Boss have been named on a strong replacements bench.
Ticket sales for Saturday's game have passed the 15,500 mark and will be on sale from Ticketmaster outlets around the ground from 2pm. Tickets are still on sale from www.leinsterrugby.ie, the Leinster Rugby Store (Donnybrook), Spar (Donnybrook), as well as Ticketmaster outlets nationwide.
LEINSTER:
15: Isa Nacewa
14: Andrew Conway
13: Gordon D'Arcy
12: Andrew Goodman
11: Fergus McFadden
10: Jonathan Sexton
9: Eoin Reddan
1: Heinke van der Merwe
2: Sean Cronin
3: Michael Bent
4: Leo Cullen CAPTAIN
5: Damian Browne
6: Kevin McLaughlin
7: Rhys Ruddock
8: Sean O'Brien
REPLACEMENTS:
16: Aaron Dundon
17: Cian Healy
18: Mike Ross
19: Tom Denton
20: Jordi Murphy
21: Isaac Boss
22: Ian Madigan
23: Fionn Carr
REFEREE: Andrew McMenenmy (SRU), ASSISTANT REFEREES: Stuart Gaffikin, Richard Kerr (both IRFU), 4th OFFICIAL: Ed Kenny (Leinster Rugby Referees), 5th OFFICIAL: John Dunne (Leinster Rugby Referees), TMO: Alan Rogan (IRFU)