But O'Driscoll, who was part of the Leinster team which lost the RaboDirect PRO12 final to the Ospreys last month, is confident that Ireland can turn it around.
"You've got to stay with them, stay with them, stay with them," O'Driscoll told the Irish Times. "And take your chances when they come. We don't have to play with any concerns, we've been written off over here already so just play with, not wild abandon, but controlled abandon, as such."
Ireland have made four changes to the line-up which lost the first Test, with O'Driscoll's Leinster teammates Mike Ross, Kevin McLaughlin and Gordon D'Arcy coming into the team for Declan Fitzpatrick, Peter O'Mahony and Keith Earls respectively.
There is also a change on the wing with Andrew Trimble replacing Munster flyer Simon Zebo who drops to the bench.
"No one gives us a chance, which is a good place to be. I know what the capabilities of the team are, and it will take a massive effort from everyone to play one of their best games," he said. "But that's happened with Irish teams I've been involved with, when we've beaten world class opposition."
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