Ulster are building a formidable record at Kingspan Stadium but their visitors are the only Welsh side to have won there since 2010, whereas Dragons face a much tougher task against Connacht, having not triumphed at the Sportsground since 2004.
Edinburgh take on Leinster at Meggetland and, historically, the Irish province have the better of these clashes - but the visitors are known for having a slow start to even their most successful campaigns.
Reigning GUINNESS PRO12 champions Glasgow Warriors, having returned from their pre-season trip to Halifax, Nova Scotia where they played the Canadian national team, face Welsh opposition when Scarlets travel to Scotstoun on Saturday.
Last season's finalists Munster are also in action on Saturday welcoming Benetton Treviso to Irish Independent Park in Cork, a venue the hosts have not lost at in the GUINNESS PRO12 since January 2013.
The round wraps up in Cardiff on Sunday when the Blues take on Zebre at BT Sports Cardiff Arms Park.
This is a repeat of the last round of the fixture of the 2014/15 regular season and Cardiff Blues will be looking for the same outcome - however, Zebre did taste victory at the ground two years ago.
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