The game will also see Peter Nelson start his first game for Ulster at outhalf. The versatile 22 year old, who has previously played 10 for Dungannon RFC and Ulster A, returns to the position following injuries to Ian Humphreys (hamstring strain) and Sam Windsor (Achilles).
Paul Marshall is selected at scrumhalf, with centres Stuart McCloskey and Luke Marshall completing the backline.
Rob Herring captains the side and starts at hooker. He is joined in the front row by Andrew Warwick who is picked at loosehead and tighthead Wiehahn Herbst.
Dan Tuohy and Franco van der Merwe are paired in the second row, with Roger Wilson named at blindside, Willie Faloon returning to competitive action with Ulster at openside and Nick Williams back from suspension to take up his position at Number 8.
Head Coach, Neil Doak, has selected six forwards and two backs on the replacements bench with John Andrew, Ricky Lutton, Bronson Ross, Peter Browne, Clive Ross and Sean Reidy named alongside David Shanahan and Sam Arnold.
The game is live on BBC 2 Northern Ireland and BBC Wales.
Fans will also be able to buy on the gate tomorrow evening, although for the best available tickets, supporters are encouraged to purchase in advance.
Ulster team & replacements to play Ospreys, Guinness PRO12, Kingspan Stadium, Friday 4th September (19:35 kick off):
(15-9): L Ludik; A Trimble, L Marshall, S McCloskey, C Gilroy, P Nelson, P Marshall; (1-8): A Warwick, R Herring (Captain), W Herbst, D Tuohy, F Van der Merwe, R Wilson, W Faloon, N Williams;
Replacements (16-23): J Andrew, R Lutton, B Ross, P Browne, C Ross, S Reidy, D Shanahan, S Arnold.
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