Kearney - who will make his 122nd appearance for the province - is named in a pacy-looking back three alongside Fitzgerald and Fionn Carr, with O'Driscoll linking up in midfield with Gordon D'Arcy. Eoin Reddan, who is set to make his 75th Leinster appearance, partners Jonathan Sexton at half back.
Leo Cullen leads an all Ireland qualified starting XV which includes the likes of Cian Healy, Jamie Heaslip and Sean O'Brien in the pack.
Shane Jennings has recovered from illness to take his place on the replacements bench alongside fellow Ireland internationals Michael Bent and Isaac Boss.
In addition to TG4 who will show the game live on Friday, the Official Leinster Supporters Club (OLSC) can confirm the following international broadcast arrangements for those supporters around the world.
UK & Ireland - Live on TG4/BBC Alba from 7.35pm Friday
Australia - Delayed on Setanta Australia from 10.50am Saturday
Asia - Delayed on Setanta Asia from 6am HKT Saturday
Unfortunately there is no coverage in New Zealand, USA, Canada or South Africa this weekend.
Our bases in London (Porterhouse Covent Garden), Birmingham (Oh Velvet) and Dubai (McGettigans) will be showing the game live. In Sydney, The Gaelic Club will be showing delayed coverage from 10.50am Saturday.
Further information from the OLSC for supporters abroad can be found at http://www.leinsterrugby.ie/olsc/abroad.php
LEINSTER:
15: Rob Kearney
14: Fionn Carr
13: Brian O'Driscoll
12: Gordon D'Arcy
11: Luke Fitzgerald
10: Jonathan Sexton
9: Eoin Reddan
1: Cian Healy
2: Sean Cronin
3: Mike Ross
4: Leo Cullen CAPTAIN
5: Devin Toner
6: Kevin McLaughlin
7: Sean O'Brien
8: Jamie Heaslip
REPLACEMENTS:
16: Aaron Dundon
17: Heinke van der Merwe
18: Michael Bent
19: Tom Denton
20: Shane Jennings
21: Isaac Boss
22: Ian Madigan
23: Andrew Conway
REFEREE: Ian Davies (WRU), ASSISTANT REFEREES: Peter Allan, Bob Nevins (both SRU), TMO: Jim Yuille (SRU) ~