The Blues will visit Leinster on Saturday as the early GUINNESS PRO12 leaders after their 61-13 thrashing of Zebre just six days earlier, their second biggest victory in the competition's history.
Danny Wilson's side scored 11 tries - equalling the competition record set by Ospreys against Benetton Treviso in 2014 - to get their season off to a flying start.
Rhys Patchell installed himself as an early leader in the race to be the GUINNESS PRO12 top point-scorer with a hat-trick of tries and a conversion.
Though he could have put more daylight between himself and the chasing pack - Josh Turnbull (15) and Jack Carty (14) are second and third respectively - were it not for seven missed kicks at goal.
And Patchell will have to be on song once more with ball in hand if the Blues are win at the RDS and condemn Leinster to successive defeats at the start of a PRO12 season for the first time since 2003.
Like Leinster, who were beaten at Edinburgh on the opening weekend, Glasgow Warriors have some catching up to do following a home defeat to the Scarlets.
Until the Welsh region came to town, Gregor Townsend's Warriors had won 20 GUINNESS PRO12 games on the bounce at Scotstoun.
They have, however, won each of their last seven matches against Connacht, who are the visitors to Scotstoun on Friday.
The Scarlets, meanwhile, face an Ulster side that made a flying start to the season with a 28-6 victory over the Ospreys at the Kingspan Stadium.
That is exactly the kind of start they had in Glasgow - Aaron Shingler's try after five minutes the fastest of Round 1 - and they may well need to repeat that if they want just a second win in name games against Ulster.
Newport Gwent Dragons host Zebre and Jason Tovey - the league's standout place kicker last weekend - will be hoping for plenty more opportunities to aim for the posts.
Tovey bisected the posts with all four of his attempts in defeat to Connacht on Friday and his side could extend Zebre's losing run in the GUINNESS PRO12 to eight.
The Ospreys host Munster seeking to avoid a third straight defeat in the competition for the first time since the 2012-13 season but they face stiff opposition.
Anthony Foley's side have only lost one of their last eight games in the competition - at the hands of the Warriors in last season's Final.
And Edinburgh travel to Benetton Treviso seeking to kick off a GUINNESS PRO12 season with back-to-back wins for the first time since 2009.
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