The rest of the XV is unchanged with a back three of Isa Nacewa - who also captains the side - Fergus McFadden and Garry Ringrose.
Noel Reid and Ben Te'o once again form the centre partnership with the aforementioned Boss partnering Cathal Marsh in the half backs.
Michael Bent starts at loosehead prop, with Aaron Dundon at hooker and Moore on the other side of the scrum. In the second row Ross Molony makes only his second ever RDS start, with the vastly experienced Mike McCarthy beside him for his 54th Leinster cap and 294th cap in professional club rugby.
In the back row Irish internationals Dominic Ryan (blindside flanker) and Jack Conan (number 8) are once again joined by Josh van der Flier, who starts at openside.
James Tracy and Rhys Ruddock are included in a match day squad for the first time this season and Ruddock hopes to make his first appearance for Leinster since March last year when he played 80 minutes against the Scarlets again in the Guinness PRO12.
Tickets for the game are on sale from ticketmaster.ie and will be available from the ticket office on the Anglesea Road gate from 1.00pm.
LEINSTER:
15: Isa Nacewa CAPTAIN
14: Fergus McFadden
13: Ben Te'o
12: Noel Reid
11: Garry Ringrose
10: Cathal Marsh
9: Isaac Boss
1: Michael Bent
2: Aaron Dundon
3: Marty Moore
4: Ross Molony
5: Mike McCarthy
6: Dominic Ryan
7: Josh van der Flier
8: Jack Conan
16: James Tracy
17: Peter Dooley
18: Jamie Hagan
19: Rhys Ruddock
20: Dan Leavy
21: Luke McGrath
22: Ross Byrne
23: Cian Kelleher
Referee: Ian Davies (WRU, 34th competition game)
Assistant Referees: Eddie Hagan-O'Connell, Shane Kierans (both IRFU)
Citing Commissioner: John Cole (IRFU)
TMO: Jude Quinn (IRFU)