Jamie Heaslip and Johnny Sexton were also confirmed as the Leinster Rugby vice-captains for the season ahead.
In team news, there are nine changes in total to the starting XV with a host of Irish internationals returning and a debut in the second row for Maori All Blacks player, Hayden Triggs.
Nacewa captains the side from full back with Fergus McFadden again selected on the right wing. Dave Kearney who started in four games during the Rugby World Cup and scored a try against Canada comes onto the left wing.
Ben Te'o and Luke Fitzgerald start in the centre for the first time together although they have played there before in the Guinness PRO12 last season at home to the Dragons when Fitzgerald came on early in the game for the injured Noel Reid.
In the half backs, Eoin Reddan makes his first start in blue of the season, while outside him Johnny Sexton makes his first appearance since his return during the summer from Racing Metro. He has 110 Leinster caps to date and 1,027 points and it will be a first game for Leinster for the 30 year old St. Mary's club man since the last game of the 2012/2013 season when Leinster beat Ulster in the PRO12 Final.
In the forwards, it is a completely new front row as Jack McGrath, Sean Cronin and Tadhg Furlong all start for the first time this season. Furlong did however feature off the bench last weekend against the Glasgow Warriors.
Six foot seven New Zealander and former Blues second row Hayden Triggs makes his debut alongside Mike McCarthy who starts for the fifth time this season.
In the back row Rhys Ruddock starts again at blindside while Jordi Murphy comes in at openside for his 61st appearance in Leinster colours since his debut in September 2011. Wicklow man Jack Conan completes the pack from number eight.
Richardt Strauss, Cian Healy and Devin Toner are all in line to make their seasonal bows from the bench as Leinster go in search of a first away win of the season.
LEINSTER:
15. Isa Nacewa CAPTAIN
14. Fergus McFadden
13. Ben Te'o
12. Luke Fitzgerald
11. Dave Kearney
10. Johnny Sexton
9. Eoin Reddan
1. Jack McGrath
2. Sean Cronin
3. Tadhg Furlong
4. Hayden Triggs
5. Mike McCarthy
6. Rhys Ruddock
7. Jordi Murphy
8. Jack Conan
16. Richardt Strauss
17. Cian Healy
18. Marty Moore
19. Devin Toner
20. Josh van der Flier
21. Luke McGrath
22. Cathal Marsh
23. Noel Reid
Referee: Andrew Brace (IRFU, 5th competition game)
Assistant Referees: Giuseppe Vivarini, Gregorio Piran (both FIR)
Citing Commissioner: Francesco Grillo (FIR)
TMO: Stefano Roscini (FIR)
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