Gregor Townsend's side kick things off in Pool 3 with a trip to France to face Racing 92 - and they will be led into battle by newly-appointed club captain Jonny Gray.
The Scarlets are leading the way in the GUINNESS PRO12 so far and their flying start to the season will be put to the test by Northampton Saints.
The Saints, who finished top of the table in the English Premiership last season, will host Wayne Pivac's side in the other Pool 3 clash.
Elsewhere on the opening weekend, Leinster will lock horns with Wasps once more after those two - both European champions in years gone by - were drawn in the same pool for the second year running.
There is an all-GUINNESS PRO12 tie in Pool 4 as Munster host Benetton Treviso, while Ulster are the visitors to Oyonnax in Pool 1.
And the Ospreys will seek to kick a slow start to the season into life when they welcome Exeter Chiefs to the Liberty Stadium.
In the Challenge Cup, Connacht - just one point off the GUINNESS PRO12 summit - begin with a trip Russia to face Enisei-STM.
Zebre begin with a trip to reigning champions Gloucester, while Edinburgh - beaten in last season's final by the Cherry & Whites - host Grenoble.
Cardiff Blues go to Italy to take on Calvisano and Newport Gwent Dragons begin a testing pool, which features French pair Pau and Castres Olympique, by hosting Sale Sharks.
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