Eighteen-year-old Blair Kinghorn keeps his starting spot at fullback with winger Damien Hoyland retaining the 14 shirt.
Will Helu moves from left wing to outside centre with Scott in at inside centre replacing the injured Sam Beard while Tom Brown replaces Helu at 11.
Fully recovered, Greig Tonks comes in at stand-off to replace the injured Phil Burleigh with scrum-half Sam Hidalgo-Clyne retaining the 9 jersey to complete the half-back partnership.
In addition to the returning front row, Alex Toolis moves up from the bench to pair Anton Bresler in the second row, replacing the unavailable Fraser McKenzie.
Mike Coman will again lead the team out at blindside, Hamish Watson returning at openside and Cornell Du Preez moving up from the bench to start in the no 8 jersey.
After opening the season with the best run of results since 2009, Edinburgh have faltered on the road over the last two weekends, most recently experiencing a bonus point defeat to Connacht in Galway.
Munster, meanwhile, have just lost one game, to date, this season, against table-toppers Scarlets though were defeated in the opening round of last season's Guinness PRO12, at home to Edinburgh.
Head coach Alan Solomons said: "We are only too aware of the challenge that we face on Saturday and know that we need to be at our best."
Saturday's Guinness PRO12 game against Munster (kick-off 5.15pm) puts the emphasis on a family afternoon out with the return of our popular 'kids for a quid' ticket offer. Tickets are available from the Ticket Centre in Roseburn Street, by phone on 0131 346 5160 and online. Adult tickets purchased before midnight tonight cost £20 (increasing to £25 on match day) while tickets for under-18s are from £1 until 5pm this evening (Friday), increasing to £5 after 5pm and on match day. Tickets for senior citizens and students are £10.
Players not considered due to injury
Michael Allen (shoulder), Sam Beard (hip), Phil Burleigh (leg), Grant Gilchrist (groin), Stuart McInally (neck), Jade Te Riure (knee), Ben Toolis (elbow)
Players not considered this week
Fraser McKenzie, David Denton
Edinburgh Rugby v Munster
Saturday 7 November 2015, BT Murrayfield, kick-off 5.15pm
15 Blair Kinghorn
14 Damien Hoyland
13 Will Helu
12 Matt Scott
11 Tom Brown
10 Greig Tonks
9 Sam Hidalgo-Clyne
1 Alasdair Dickinson
2 Ross Ford
3 WP Nel
4 Anton Bresler
5 Alex Toolis
6 Mike Coman (captain)
7 Hamish Watson
8 Cornell Du Preez
Substitutes
16 Neil Cochrane
17 Rory Sutherland
18 John Andress
19 Roddy Grant
20 Nasi Manu
21 Sean Kennedy
22 Andries Strauss
23 Dougie Fife
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