The reigning Premiership champions have beaten the Ulstermen in each of their last three European meetings, including quarter-final clashes in both 2013 and 2014.
They also got their Champions Cup campaign off to a flying start with an impressive 32-7 triumph over four-time winners Toulouse.
Ulster, on the other hand, saw their opener against Oyonnax postponed, so their last outing was a 19-12 victory at Rodney Parade in the GUINNESS PRO12:
That should ensure Les Kiss' side are fresh to take on the likes of flying wingers Chris Wyles, who dotted down twice against Toulouse, and Chris Ashton.
Rising star Maro Itoje is also one to watch out for in the second row, while veteran centre Brad Barritt captains Saracens on the outside of fly-half Owen Farrell.
Friday November 20, kick-off 7:45pm UK/Ire
Ulster: Louis Ludik, Andrew Trimble, Darren Cave, Stuart McCloskey, Craig Gilroy, Paddy Jackson, Ruan Pienaar, Callum Black, Rory Best, Wiehahn Herbst, Dan Tuohy, Franco van der Merwe, Iain Henderson, Chris Henry, Nick Williams
Replacements: Kyle McCall, Rob Herring, Ricky Lutton, Robbie Diack, Roger Wilson, Paul Marshall, Ian Humphreys, Peter Nelson
Saracens: Alex Goode, Chris Ashton, Duncan Taylor, Brad Barritt, Chris Wyles, Owen Farrell, Richard Wigglesworth, Mako Vunipola, Schalk Brits, Petrus Du Plessis, George Kruis, Maro Itoje, Michael Rhodes, Jacques Burger, Billy Vunipola
Replacements: Jamie George, Rhys Gill, Juan Figallo, Alistair Hargreaves, Jackson Wray, Neil De Kock, Charlie Hodgson, Marcelo Bosch
In the Challenge Cup, Cardiff Blues take on a Harlequins re-born as the in-form 2011 Challenge Cup champions descend on the Welsh capital.
Last season was a frustrating one for Conor O'Shea's side but they have kicked off the new campaign in style, including a 38-28 win away at last season's Premiership finalists Bath late last month.
They also beat Montpellier 41-18 last weekend but the Blues have discovered their try-scoring edge too, if recent results are anything to go by - a 50-point display in Italy last weekend and a thrilling 35-30 defeat to Glasgow Warriors before that:
The Blues will know a thing or two about Quins winger Tim Visser, who arrived from GUINNESS PRO12 side Edinburgh in the summer.
However, they would also be wise to keep an eye on the fleet-footed Charlie Walker - on the other wing - as well as 21-year-old centre Harry Sloan and in-form flanker Jack Clifford, who captains the side at the age of 22.
Thursday November 19, kick-off 7:45pm UK/Ire
Cardiff Blues: Blaine Scully, Alex Cuthbert, Rey Lee-Lo, Gavin Evans, Tom James, Rhys Patchell, Lloyd Williams, Gethin Jenkins, Kristian Dacey, Tau Filise, Jarrad Hoeata, James Down, Ellis Jenkins, Sam Warburton, Josh Turnbull
Replacements: Matthew Rees, Sam Hobbs, Dillon Lewis, Lou Reed, Manoa Vosawai, Tavis Knoyle, Jarrod Evans, Dan Fish
Harlequins: Ollie Lindsay- Hague, Charlie Walker, Matt Hopper, Harry Sloan, Tim Visser, Ben Botica, Karl Dickson, Mark Lambert, Rob Buchanan, Kyle Sinckler, Charlie Matthews, Sam Twomey, James Chisholm, Jack Clifford, Nick Easter
Replacements: Joe Gray, Joe Marler, Will Collier, Kieran Treadwell, Dave Ward, Danny Care, Winston Stanley, Tim Swiel
And Edinburgh head to France to take on an Agen side that lost 48-10 to London Irish in their opener.
The Premiership strugglers cut loose last weekend, running in eight tries, while Edinburgh also made a winning start - beating Grenoble 28-10 on home soil - to bounce back from defeat to Munster:
The secret to Edinburgh's success could well be keeping quiet the half-back partnership of captain Clement Darbo and stand-off Francois Bouvier, while wing duo Leka Tagotago and Filipo Nakosi are a threat.
Friday November 20, kick-off 6:30pm UK/Ire
Agen: François Tardieu, Leka Tagotago, Pierre Fouyssac, Julien Heriteau, Filipo Nakosi, François Bouvier, Clement Darbo, Quentin Bethune, Marc Barthomeuf, Nicolas Chocou, Jean-Baptiste Roidot, Léo Bastien, Sione Tau, Antoine Miquel, Marc Baget
Replacements: Florian Dufour, Viliamu Afatia, Dave Ryan, Corentin Braendlin, Felicien Vergnon, Baptiste Cadiou, Timothé Guillimin, Benoit Sicart
Edinburgh: Dougie Fife, Tom Brown, William Helu, Matt Scott, Otulea Katoa, Greig Tonks, Sean Kennedy, Alasdair Dickinson, Ross Ford, WP Nel, Anton Bresler, Fraser McKenzie, Nasi Manu, John Hardie, Cornell Du Preez
Replacements: Neil Cochrane, Rory Sutherland, Simon Berghan, Alex Toolis, Jamie Ritchie, Nathan Fowles, Blair Kinghorn, Chris Dean
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