Rob Kearney is again selected to start from full back, although he failed a late fitness test last week and didn't start with Isa Nacewa filling in for the 67 times Irish capped full back.
Zane Kirchner is again selected on the right wing with Dave Kearney coming in on the left. Last week's Guinness PRO12 Man of the Match Luke Fitzgerald moves from the left wing to inside centre for his 145th Leinster cap. Ben Te'o will line up alongside him at 13.
In the half backs Ian Madigan shifts from the centre to number 10, with Eoin Reddan starting at scrumhalf in his 125th appearance in blue. Reddan came on after 31 minutes against Ulster for the injured Luke McGrath.
It's a completely new front row as Cullen calls up three Irish capped front rowers in Cian Healy, Richardt Strauss and Marty Moore, while Tom Denton comes in to partner Mike McCarthy in the second row.
Rhys Ruddock and Josh van der Flier will start at blind side and open side respectively, while Jordi Murphy comes in at the base of the scrum. Rudock will also captain the team for the first time this season as he closes in on 100 caps for the province.
LEINSTER:
15. Rob Kearney
14. Zane Kirchner
13. Ben Te'o
12. Luke Fitzgerald
11. Dave Kearney
10. Ian Madigan
9. Eoin Reddan
1. Cian Healy
2. Richardt Strauss
3. Marty Moore
4. Tom Denton
5. Mike McCarthy
6. Rhys Ruddock CAPTAIN
7. Josh van der Flier
8. Jordi Murphy
16. Sean Cronin
17. Peter Dooley
18. Tadhg Furlong
19. Ross Molony
20. Dominic Ryan
21. Isaac Boss
22. Cathal Marsh
23. Garry Ringrose
Referee: Nigel Owens (WRU, 129th competition game)
Assistant Referees: Lloyd Linton, Dunx McClement (both SRU)
Citing Commissioner: Paul Minto (SRU)
TMO: Jim Yuille (SRU)
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