Racing 92 v Scarlets
Scarlets will be up against it if they are to stop Racing 92 qualifying for the knock-out stages of the Champions Cup.
The French giants once again boast the likes of international legends Dan Carter and Mike Phillips in their ranks, and are looking to stay unbeaten in European competition this season to earn themselves a home quarter-final.
Scarlets have lost their last five games away in Europe, but wrecked Racing's European hopes two years ago at the exact same stage of the group with a 19-13 win at Colombes.
Sunday, 1pm, Stade Yves-Du-Manoir
Racing 92: 15 Brice Dulin, 14 Louis Dupichot, 13 Dan Carter, 12 Casey Laulala, 11 Juan Imhoff, 10 Remi Tales, 9 Mike Phillips, 1 Eddy Ben Arous, 2 Dimitri Szarzewski (capt), 3 Ben Tameifuna, 4 Luke Charteris, 5 Manuel Carizza, 6 Yannick Nyanga, 7 Bernard Le Roux, 8 Antonie Claassen
Replacements: Camille Chat, Julien Brugnaut, Martin Castrogiovanni, Thibault Dubarry, Chris Masoe, Maxime Machenaud, Henry Chavancy, Johannes Goosen
Scarlets: 15 Michael Collins, 14 Steffan Evans, 13 Regan King, 12 Hadleigh Parkes, 11 DTH van der Merwe, 10 Steven Shingler, 9 Gareth Davies, 1 Phil John, 2 Ken Owens (capt), 3 Samson Lee, 4 George Earle, 5 Maselino Paulino, 6 Rory Pitman, 7 Aaron Shingler, 8 Morgan Allen
Replacements: Kirby Myhill, Wyn Jones, Rhodri Jones, Tom Price, Tom Phillips, Rhodri Williams, Daniel Jones, Steffan Hughes
Northampton Saints v Glasgow Warriors
With Racing 92 streaking away with Pool 3, only a win will do for both sides if they are to keep their hopes of qualification alive.
It has been a rollercoaster week for Northampton, who came so close to overturning a 21-point deficit at Leicester Tigers before eventually losing, and also saw prop Alex Corbisiero announce his immediate departure from the Gardens.
Glasgow can overhaul the English side to go second in the Pool with a win, but they will need to avenge their 26-15 loss at Scotstoun in Round 2 without Mark Bennett and Peter Horne, who are injured.
Sunday, 5.30pm, Franklin's Gardens
Northampton Saints: 15 Ben Foden, 14 Tom Collins, 13 George Pisi, 12 Luther Burrell, 11 George North, 10 JJ Hanrahan, 9 Lee Dickson (c); 1 Alex Waller, 2 Dylan Hartley, 3 Paul Hill, 4 Courtney Lawes, 5 Christian Day, 6 Jamie Gibson, 7 Tom Wood, 8 Teimana Harrison.
Replacements: 16 Mike Haywood, 17 Ethan Waller, 18 Gareth Denman, 19 Michael Paterson, 20 Jon Fisher, 21 Tom Kessel, 22 Stephen Myler, 23 Harry Mallinder
Glasgow Warriors: 15 Stuart Hogg, 14 Lee Jones, 13 Alex Dunbar, 12 Sam Johnson, 11 Sean Lamont, 10 Finn Russell, 9 Ali Price; 1 Gordon Reid, 2 Pat MacArthur, 3 Sila Puafisi, 4 Leone Nakarawa, 5 Jonny Gray (c), 6 Ryan Wilson, 7 Chris Fusaro, 8 Adam Ashe
Replacements: 16 Shalva Mamukashvili, 17 Alex Allan, 18 Zander Fagerson, 19 Tim Swinson, 20 Simone Favaro, 21 Grayson Hart, 22 Duncan Weir, 23 Taqele Naiyaravoro
Challenge Cup
Harlequins v Cardiff Blues
If they are to reach the knock-out stages of this year's competition, Cardiff Blues know it is crunch time and that they must beat Harlequins away from home.
The star-studded English side are unbeaten in six games, and are yet to lose at home in all competitions this season after shocking Saracens last weekend.
Quins meanwhile would wrap up qualification for the knock-out stage as well as the all-important home quarter-final with a win, and one man to look out for is former Blues star Jamie Roberts, who starts at centre.
Sunday, 3.15pm, Twickenham Stoop
Harlequins: 15 Mike Brown, 14 Marland Yarde, 13 George Lowe, 12 Jamie Roberts, 11 Ross Chisholm, 10 Nick Evans, 9 Danny Care, 1 Joe Marler, 2 Rob Buchanan, 3 Will Collier, 4 George Merrick, 5 Charlie Matthews, 6 Chris Robshaw, 7 Jack Clifford, 8 Nick Easter
Replacements: Dave Ward, Mark Lambert, Kyle Sinckler, Mat Luamanu, Luke Wallace, Karl Dickson, Ben Botica, Charlie Walker
Cardiff Blues: 15 Dan Fish, 14 Alex Cuthbert, 13 Cory Allen, 12 Ray Lee-Lo, 11 Tom James, 10 Rhys Patchell, 9 Lloyd Williams, 1 Sam Hobbs, 2 Kristian Dacey, 3 Taufa'ao Filise, 4 Macauley Cook, 5 James Down, 6 Josh Turnbull, 7 Manoa Vosawai, 8 Josh Navidi
Replacements: Ethan Lewis, Tom Davies, Dillon Lewis, Jarrard Hoeata, Ellis Jenkins, Tavis Knoyle, Gareth Anscombe, Gavin Evans