But Davies has been superb in his own right for Wales in recent months and it was Twickenham where he finished off a breakaway try that helped stun the English at the Rugby World Cup back in September.
So he will not be daunted and neither will be unflappable Osprey Biggar, a man who went down in Welsh folklore by kicking the winning penalty on that famous night.
In the pack, another Osprey in Alun Wyn Jones will bring his usual poise to the set-piece and will look to dominate a so-far impressive George Kruis for England.
The trio help make up a total of 11 Guinness PRO12 players in Wales' starting line-up, while five more can be called upon from the bench.
At BT Murrayfield, Scotland go for their first home RBS 6 Nations victory in three years against France and Glasgow Warriors' powerhouse No.8 Josh Strauss has been drafted into the team to help achieve that.
It was only a matter of time before Strauss received the call-up having been in fine form for the Glasgow Warriors - he won man-of-the-match as they beat Munster last month.
After recovering from a horrendous run of injuries, Alex Dunbar is another Warrior back in the fold for Scotland while his teammate Mark Bennett makes way in the centres.
They are part of an 11-man Guinness PRO12 contribution to Scotland's starting XV, while there are seven waiting in the wings among the replacements.
Ireland and Italy clash at the Aviva Stadium in a bid to end their winless streaks at this year's Championship, and both Joe Schmidt and Jacques Brunel have been forced into some tweaks.
With Leinsterman Rob Kearney injured Munster's Simon Zebo slots in at full-back, though Ulster back Jared Payne comes back at outside centre - replacing his teammate Stuart McCloskey.
And there could be a first cap for Connacht prop Finlay Bealham from the bench after Cian Healy pulled up with a hamstring strain during the week.
For Italy, Zebre half-backs Guglielmo Palazzani and Edoardo Padovani are the new pairing, with Kelly Haimona dropped to the bench and Benetton Treviso's Edoardo Gori injured.
Zebre veteran George Biagi comes back into the second row and Treviso hooker Davide Giazzon makes just his fourth Test start.
With 18 Italian Guinness PRO12 representatives and a full 23 for the Irish, that brings the league's contribution to Round 4 of the RBS 6 Nations up to 75 players.
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