Having lifted the trophy with Glasgow Warriors less than 12 months ago, the former Scotland international second-row will once again be involved in the showpiece event on Saturday 28 May 2016.
Kellock has followed the trend of retiring professionals who have moved into refereeing, such as former Warrior Mike Adamson and New Zealander Glen Jackson.
Since retiring as a player last May, Kellock has undertaken a rigorous, fast-tracked training behind the scenes to become a referee and after passing all mandatory assessments, including a vigorous eye assessment at Specsavers, Kellock is now ready to take the whistle in professional matches.
Following his success of officiating at grassroots level games, Kellock is set to take charge of a number of Guinness PRO12 games over the next two months, across all four competing nations, ahead of the Final in May.
Guinness PRO12 Final referee, Al Kellock, said: "I'm honoured to have been appointed referee for the Guinness PRO12 Final at BT Murrayfield in May.
"It's been a long, hard few months to get to this stage but I feel I'm now ready to give something back to the game and a competition which is so close to my heart.
"I've been trying to referee games for the last 20 years and following my retirement as a player I felt this was the next logical step in my career.
"My mentor Nigel Owens has been very supportive and encouraged me to pursue this new career move."
Fellow Guinness PRO12 referee, Nigel Owens, said: "Whilst I'm disappointed to miss out on the Final, I couldn't be happier for Al and I think he's the perfect fit for this showpiece event.
"It's great to see retiring professionals stay in the game and give back to the sport and hopefully it will pave the way for others to follow suit."
Guinness PRO12 tournament director, David Jordan, added: "We're delighted to appoint Al Kellock as referee for the Guinness PRO12 Final.
"He is highly regarded in the game and as a former captain of the defending champions, he understands what it takes to perform at the highest level.
"We have no doubt his professionalism as a player will translate into his new role as a match official."
Tickets for the Guinness PRO12 Final (Saturday 28 May) are available now from scottishrugby.org.
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