In the forwards, Luke Charteris' absence with the Wales squad means that Jevon Groves moves into the second row and Darren Waters comes in at open side.
Lewis Rolbling continues at 10 after his impressive outing on his first start at fly-half against Munster.
On the bench, Newport's Hywel Stoddart is selected in the Dragons squad for the first time as back row cover.
Newport Gwent Dragons Team
15 Martyn Thomas
14 Will Harries
13 Andy Tuilagi
12 Ashley Smith (C)
11 Aled Brew
10 Lewis Robling
9 Wayne Evans
1 Nathan Williams
2 Steve Jones
3 Nathan Buck
4 Jevon Groves
5 Rob Sidoli
6 Lewis Evans
7 Darren Waters
8 Tom Brown
Replacements
16 Sam Parry
17 Phil Price
18 Dan Way
19 Hugo Ellis
20 Hywel Stoddart
21 Joe Bedford
22 Tonderai Chavhanga
23 Steffan Jones
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