Aled Brew is also named in the starting line-up before a summer move abroad and will make his 100th start for the Dragons against the Heineken Cup finalists.
Outside centre Adam Hughes also reaches a landmark for the Dragons as he earns his cap for 50 starts for the region.
The Dragons have retained 17 year old Monmouth Boys School pupil Hallam Amos at full back and he is joined by fellow 17 year old Jack Dixon who is named on the bench. Scrum half Jonathan Evans makes it a trio of teenagers in the matchday squad after he was named on the bench. Both Evans and Dixon have recently been named in Danny Wilson's Wales U20 squad for this summer's Junior World Championship in South Africa.
Will Harries comes into the side on the wing in place of Tonderai Chavhanga who had minor knee surgery last week on an injury sustained in the Dragons last match against the Ospreys.
Sam Parry is the only other change to the side selected to face the Ospreys as he comes in at hooker for Steve Jones.
Newport Gwent Dragons Team
15 Hallam Amos
14 Will Harries
13 Adam Hughes
12 Ashley Smith
11 Aled Brew
10 Lewis Robling
9 Wayne Evans
1 Nathan Williams
2 Sam Parry
3 Nathan Buck
4 Luke Charteris (c)
5 Rob Sidoli
6 Danny Lydiate
7 Lewis Evans
8 Toby Faletau
Replacements
16 Steve Jones
17 Phil Price
18 Dan Way
19 Jevon Groves
20 Tom Brown
21 Jonathan Evans
22 Pat Leach
23 Jack Dixon
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