New signing Ian Nimmo is set to make his first ever Pro12 appearance, whilst Welsh internationals Dan Evans and Tom Prydie return to the competition in Dragons colours.
Dragons season ticket holders are reminded that they have a voucher for Friday's game.
Dragons squad for Zebre
Dan Evans, Tom Prydie, Will Harries, Andy Tuilagi, Ashley Smith, Jack Dixon, Pat Leach, Lewis Robling, Steffan Jones, Wayne Evans, Jonathan Evans, Tom Brown, Toby Faletau, Hywel Stoddart, Dan Lydiate, Jevon Groves, Andrew Coombes, Adam Jones, Ian Nimmo, Dan Way, Nathan Buck, Nathan Williams, Phil Price, Hugh Gustafson, Sam Parry, Steve Jones.
Players not selected through injury;
Joe Bedford, Adam Hughes, Tonderai Chavhanga, Jamie Smith, Matthew Pewtner, Dan Watchurst, Darren Waters, Lewis Evans, Rob Sidoli
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