In the forwards, Luke Charteris is named in the starting line-up alongside Rob Sidoli in the second row with Jevon Groves slotting into the back row in place of Lewis Evans after impressing in his last few starts.
There are also a couple of changes in the front row. Sam Parry is in line to make his first RaboDirect PRO12 start at hooker instead of Steve Jones whilst Dan Way starts ahead of Nathan Buck at prop.
The Dragons have named a new pair of half backs in Joe Bedford and Steffan Jones, who is given his chance in the fly half slot after a couple of outings by Lewis Robling.
Will Harries moves from wing to full back to accommodate Tonderai Chavhanga's return to the starting line-up. Adam Hughes has recovered from the facial injury he sustained out in Aironi and replaces Andy Tuilagi who misses out with a dead leg.
Newport Gwent Dragons
15 Will Harries
14 Tonderai Chavhanga
13 Adam Hughes
12 Ashley Smith
11 Aled Brew
10 Steffan Jones
9 Joe Bedford
1 Nathan Williams
2 Sam Parry
3 Dan Way
4 Luke Charteris (c)
5 Rob Sidoli
6 Jevon Groves
7 Darren Waters
8 Tom Brown
Replacements
16 Steve Jones
17 Phil Price
18 Nathan Buck
19 Hywel Stoddart
20 Lewis Evans
21 Wayne Evans
22 Lewis Robling
23 Martyn Thomas
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