Gordon D'Arcy partners Brian O'Driscoll at centre with Isaac Boss - a try scorer in Newport - and Jonathan Sexton continuing their half-back partnership.
In all there are six Ireland internationals in the starting pack with props Cian Healy and Mike Ross returning to the front row and Kevin McLaughlin forming a back-row unit alongside Sean O'Brien and Jamie Heaslip.
Leo Cullen leads the team and partners Scotland's Nathan Hines at second row.
Internationals Heinke van der Merwe, Stan Wright, Devin Toner, Rhys Ruddock, Eoin Reddan and Fergus McFadden are named amongst a strong replacements bench.
LEINSTER:
15: Isa Nacewa
14: Shane Horgan
13: Brian O'Driscoll
12: Gordon D'Arcy
11: Luke Fitzgerald
10: Jonathan Sexton
9: Isaac Boss
1: Cian Healy
2: Richardt Strauss
3: Mike Ross
4: Leo Cullen CAPTAIN
5: Nathan Hines
6: Kevin McLaughlin
7: Sean O'Brien
8: Jamie Heaslip
REPLACEMENTS:
16: Aaron Dundon
17: Heinke van der Merwe
18: Stan Wright
19: Devin Toner
20: Rhys Ruddock
21: Eoin Reddan
22: Ian Madigan
23: Fergus McFadden