In the starting XV Alberto Sgarbi, who suffered back problems in the last Six Nations game against Scotland, returns to action, as does winger Andrew Vilk in the backs.
Several new faces feature in the forwards too. Both locks Antonio Pavanello and Corniel Van Zyl will be back, while Ignacio Fernandez Rouyet will be moved to loose-head prop and Lorenzo Cittadini will feature as tight-head.
In the back row, Manoa Vosawai will play as flanker, while Brendan Williams starts from the bench
Here is the team for the match:
15 Luke McLean
14 Michele Sepe
13 Alberto Sgarbi
12 Gonzalo Garcia
11 Andrew Vilk
10 Kristopher Burton
9 Fabio Semenzato
8 Robert Barbieri
7 Benjamin Vermaak
6 Manoa Vosawai
5 Corniel Van Zyl
4 Antonio Pavanello (captain)
3 Lorenzo Cittadini
2 Leonardo Ghiraldini
1 Ignacio Fernandez Rouyet
Replacements:
16 Diego Vidal
17 Michele Rizzo
18 Pedro Di Santo
19 Valerio Bernabò
20 Gonzalo Padrò
21 Paul Derbyshire
22 Simon Picone
23 Brendan Williams
Head Coach: Franco Smith.