Eoin Reddan links up at half-back with 22-year-old Ian Madigan who is making his 15th appearance of the current campaign.
In the pack, Cian Healy and Mike Ross form the front row alongside hooker Jason Harris-Wright with Devin Toner starting alongside Scotland's Nathan Hines at second row. Ireland trio Shane Jennings, Sean O'Brien and Rhys Ruddock make up the back row.
Shane Horgan, who scored two tries in the 34-26 victory over Ulster last weekend, is one of four Ireland internationals on the replacements bench including Isaac Boss, Leo Cullen and Jonathan Sexton.
LEINSTER:
15: David Kearney
14: Fergus McFadden
13: Brian O'Driscoll CAPTAIN
12: Eoin O'Malley
11: Luke Fitzgerald
10: Ian Madigan
9: Eoin Reddan
1: Cian Healy
2: Jason Harris-Wright
3: Mike Ross
4: Devin Toner
5: Nathan Hines
6: Rhys Ruddock
7: Shane Jennings
8: Sean O'Brien
REPLACEMENTS:
16: Richardt Strauss
17: Heinke van der Merwe
18: Stan Wright
19: Leo Cullen
20: Dominic Ryan
21: Isaac Boss
22: Jonathan Sexton
23: Shane Horgan
REFEREE: Andrew McMenemy (SRU), ASSISTANT REFEREES: Mauro Dordolo, Claudio Blessano (both FIR)