Jack McGrath makes his sixth Magners League appearance in the front row alongside Richardt Strauss and Stan Wright.
Gordon D'Arcy lines up alongside Eoin O'Malley (who has featured in 19 games so far this season) at centre. Fergus McFadden, meanwhile, is set to bring up his half century of caps in Leinster colours.
Cian Healy is one of four international forwards on the bench alongside Nathan Hines, Mike Ross and Rhys Ruddock.
LEINSTER:
15: Isa Nacewa
14: Shane Horgan
13: Eoin O'Malley
12: Gordon D'Arcy
11: Fergus McFadden
10: Ian Madigan
9: Isaac Boss
1: Jack McGrath
2: Richardt Strauss
3: Stan Wright
4: Kevin McLaughlin
5: Devin Toner
6: Dominic Ryan
7: Shane Jennings
8: Jamie Heaslip CAPTAIN
REPLACEMENTS:
16: Aaron Dundon
17: Cian Healy
18: Mike Ross
19: Nathan Hines
20: Rhys Ruddock
21: Paul O'Donohoe
22: Ian McKinley
23: David Kearney
REFEREE: James Jones (WRU), ASSISTANT REFEREES: Simon McDowell, Mark Patton (both IRFU), 4th OFFICIAL: Kevin Beggs (Leinster Rugby Referees), 5th OFFICIAL: Wayne Sheridan (Leinster Rugby Referees), TMO: Peter Ferguson (IRFU)