Simon Danielli, Joe Ansbro and Rory Lawson are all called into the back division, while Nathan Hines is named in the back row.
Ulster's Danielli makes his first start in the 2011 Championship while Ansbro returns from injury in the midfield. Lawson regains the number 9 jersey while in the pack, Hines is re-introduced on the blindside while Saracens' Kelly Brown moves to No 8.
Scotland team: Paterson (Edinburgh); Danielli (Ulster), Ansbro (Northampton), S Lamont Scarlets), M Evans (Glasgow Warriors); Jackson (Glasgow Warriors), R Lawson (Gloucester); Jacobsen (Edinburgh), Ford (Edinburgh), Low (Glasgow Warriors), Gray (Glasgow Warriors), Kellock (Glasgow Warriors, captain), Hines (Leinster), Barclay (Glasgow Warriors), Brown (Saracens).
Replacements: S Lawson (Gloucester), Cross (Edinburgh), Vernon (Glasgow Warriors), Strokosch (Gloucester), Blair (Edinburgh), Parks (Cardiff Blues), De Luca (Edinburgh).