Both Tiernan O'Halloran and Fetu'u Vainikolo return to their starting positions on the wing while Eoin Griffin joins Dave McSharry in the centre.
Dan Parks makes a welcome return to rugby and his debut for the province tomorrow night as out half.
Up front, Brett Wilkinson makes way for Denis Buckley as loosehead prop while former Leinster prop Nathan White, who also captains the side, starts again as tighthead prop.
Michael Swift, who earns his 150th league appearance on the eve of this derby game, slots back into the second row and is joined by fellow second rower Mike McCarthy.
Eoin McKeon who started the last two weeks in the number 8 position moves to blindside flanker and joins Johnny O'Connor and George Naoupu in the back row.
KO for Connacht v Leinster is 8pm in the Sportsground.
Connacht XV
15. Robbie Henshaw
14. Tiernan O'Halloran
13. Eoin Griffin
12. Dave McSharry
11. Fetu'u Vainikolo
10. Dan Parks
9. Kieran Marmion
1. Denis Buckley
2. Adrian Flavin
3. Nathan White (captain)
4. Michael Swift
5. Mike McCarthy
6. Eoin McKeon
7. Johnny O'Connor
8. George Naoupu
Replacements (from):
16. Jason Harris-Wright
17. Brett Wilkinson
18. Ronan Loughney
19. Dave Gannon
20. Willie Faloon
21. Dave Moore
22. Miah Nikora
23. Mata Fifita