Isaac Boss again partners Jonathan Sexton at half back, with D'Arcy linking up with Fergus McFadden at centre, with Isa Nacewa returning to the wing after being rested last week.
Up front, Healy joins Richardt Strauss and Mike Ross in the front row with skipper Cullen starting at second row alongside Devin Toner. Brian O'Driscoll, after further testing, has been given an extra week to recover from the 'stinger' he suffered during the World Cup.
The likes of Sean Cronin, Kevin McLaughlin, Eoin Reddan and Rhys Ruddock are included on the Leinster replacements bench for the game which is already set to be played in front of over 46,000 supporters and counting, making it the third largest attendance in league history.
Last year's record attendance was 50,645 against Munster in the Aviva Stadium (2nd October 2010) and the previous record crowd of 48,000 attended 'The Last Stand' against Ulster in Lansdowne Road (31st December 2006).
Tickets are still on sale from www.leinsterrugby.ie, the Leinster Rugby Store (Donnybrook), Spar (Donnybrook) as well as Ticketmaster outlets nationwide.
*Please note that due to essential ongoing maintenance work at Lansdowne Road DART station, the station will not be in use for supporters on Friday. Supporters are asked to alight from either Grand Canal Dock (those travelling from the north of the city) or Sydney Parade (those travelling from the south of the city) stations. The DART will not operate between Grand Canal Dock - Sydney Parade - Grand Canal Dock.
LEINSTER:
15: Rob Kearney
14: Isa Nacewa
13: Fergus McFadden
12: Gordon D'Arcy
11: Luke Fitzgerald
10: Jonathan Sexton
9: Isaac Boss
1: Cian Healy
2: Richardt Strauss
3: Mike Ross
4: Leo Cullen CAPTAIN
5: Devin Toner
6: Sean O'Brien
7: Shane Jennings
8: Jamie Heaslip
REPLACEMENTS:
16: Sean Cronin
17: Heinke van der Merwe
18: Jamie Hagan
19: Kevin McLaughlin
20: Rhys Ruddock
21: Eoin Reddan
22: Ian Madigan
23: Eoin O'Malley
REFEREE: Pascal Gauzere (FFR), ASSISTANT REFEREES: David Wilkinson, Simon McDowell (both IRFU), 4th OFFICIAL: John Montayne (Leinster Rugby Referees), 5th OFFICIAL: Tom Tuohy (Leinster Rugby Referees), TMO: Marshall Kilgore (IRFU)