Damian Browne lines up alongside Devin Toner while Jordi Murphy comes in for his first senior start after also coming off the bench against Glasgow Warriors.
The backline is unchanged meaning Cillian Willis partners Ian Madigan at half-back. Eoin O'Malley again lines up alongside Luke Fitzgerald at centre with David Kearney, Fionn Carr and Isa Nacewa completing the back three.
LEINSTER:
15: Isa Nacewa
14: Fionn Carr
13: Eoin O'Malley
12: Luke Fitzgerald
11: David Kearney
10: Ian Madigan
9: Cillian Willis
1: Heinke van der Merwe
2: Richardt Strauss
3: Nathan White
4: Damian Browne
5: Devin Toner
6: Rhys Ruddock CAPTAIN
7: Jordi Murphy
8: Leo Auva'a
REPLACEMENTS:
16: Jason Harris-Wright
17: Jack McGrath
18: Jamie Hagan
19: Mark Flanagan
20: Ciaran Ruddock
21: John Cooney
22: Brendan Macken
23: Darren Hudson
REFEREE: John Lacey (IRFU), ASSISTANT REFEREES: Neil Hennessy, Hugh Watkins (both WRU), TMO: Tony Rowlands (WRU)