Steven Sykes will make his competitive debut for the province and he joins Ireland international Devin Toner at second row in a pack which sees Ciaran Ruddock, who will make his 2nd provincial appearance, join his brother Rhys in the back-row.
Jamie Hagan joins Richardt Strauss and Heinke van der Merwe in the front row.
Academy out-half Noel Reid comes in for his senior debut and the 21-year-old partners Cillian Willis at half back in the only change to the backline which started last weekend's 15-10 victory away to the Scarlets.
This means that Luke Fitzgerald continues his centre partnership with Eoin O'Malley while Isa Nacewa - who has kicked 45 points so far this season at an 84% success ratio - continues at full-back.
Over 14,700 tickets have now been sold for Saturday's game which will include the usual 'Family Day' activities and tickets will be sold around the ground on the day and are still available online from www.leinsterrugby.ie, Spar (Donnybrook), the Leinster Rugby Store and Ticketmaster outlets nationwide.
LEINSTER:
15: Isa Nacewa
14: Fionn Carr
13: Eoin O'Malley
12: Luke Fitzgerald
11: Dave Kearney
10: Noel Reid
9: Cillian Willis
1: Heinke van der Merwe
2: Richardt Strauss
3: Jamie Hagan
4: Steven Sykes
5: Devin Toner
6: Ciaran Ruddock
7: Rhys Ruddock CAPTAIN
8: Leo Auva'a
REPLACEMENTS:
16: Jason Harris-Wright
17: Jack McGrath
18: Jack O'Connell
19: Damian Browne
20: Jordi Murphy
21: John Cooney
22: Ian Madigan
23: Brendan Macken
REFEREE: Marius Mitrea (FIR), ASSISTANT REFEREES: Leo Colgan, Mark Hermin (both IRFU), 4th OFFICIAL: Nigel Correll (Leinster Rugby Referees), 5th OFFICIAL: Andrew Baird (Leinster Rugby Referees)
Guinness PRO12
Suite 208, Alexandra House,
The Sweepstakes
Ballsbridge, Dublin 4, Ireland