Matt Banahan, returning from World Cup duty with England to earn his 100th Bath cap, winger Tom Biggs and debutant Olly Woodburn all went over in the first-half for the visitors.
Fellow debutant Will Spencer followed suit after the break, while Jack Cuthbert and Anthony Perenise added further misery for Darren Edwards' side, who suffered a record-equaling 30-point home defeat.
Fly-half Tom Heathcote finished with a haul of 11 points after kicking four conversions and a penalty while Matthew Jones replied with a conversion and three penalties for the Dragons.
But the game was marred by a serious-looking injury to Bath scrum-half Mark McMillan who was taken off the field on a stretcher with a suspected neck injury.
Scarlets fared better against English powerhouses Leicester Tigers with No 8. Kieran Murphy grabbing two tries in a resounding 31-3 bonus-point victory at Parc y Scarlets.
The 24-year-old opened the scoring early on for Nigel Davies' side and added a second on 33 minutes in a dominant display.
Flanker Matt Gilbert, winger Liam Williams and fly-half Jordan Williams also crossed for Scarlets while Williams also kicked two conversions.
Aled Thomas also converted but the best the Tigers could offer was a George Ford penalty in the first half.
Greg Goosen's hat-trick for Newcastle Falcons left the Blues reeling with Rhys Patchell's penalty the only score for hte Welsh side.
A second minute Mark Wilson try was followed by Goosen's first five minutes later and the South African crossed again either side of half-time to secure a bonus point, with Michael Mayhew sealing the game on the hour mark.
Ospreys unbeaten start to the season came to an end as an inexperienced side were thrashed 35-9 by Exeter Chiefs.
However there were positives for the visitors as Wales U20 stars Eli Walker and Matthew Morgan both looked dangerous with ball in hand.
However the inexperience in the front five proved costly as the Welsh side finished with just three Morgan penalties to show for their efforts.
Prop John Andress, Phil Dollman and Josh Tatupu added to an early penalty try for the Chiefs to end the Ospreys' six-match winning run.
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