Alongside him at fly-half will be Jackson, the duo entrusted by interim Scotland head coach Scott Johnson to get the team flowing.
Glasgow's Jackson twice replaced his Edinburgh counterpart in last season's Six Nations but the pair have never started a Championship game at half-back together, something Laidlaw can't wait to change.
"It is very exciting to be playing alongside Ruaridh and I think that underlines that Scott Johnson really wants us to play the game on the front foot and take the match to England," Laidlaw told the Glasgow Evening Times.
"If we can get quick ball then Scott has pretty much given us a free rein to take the game to the English and play at the highest tempo we can, as flat to the gain line as possible.
"I think for us as a group of players that is really energising. But obviously Ruaridh plays with a lot of flair and given this will be the first time we have started in tandem at nine and ten it is a very exciting prospect.
"I watched Ruaridh's performance against Northampton in the Heineken Cup recently and he was outstanding.
"He ran the show against one of the best teams in England and there is no doubt he can do the same against the English international side at Twickenham.
"I think Ruaridh is a big-game player and they don't get much bigger than the Calcutta Cup match at Twickenham."
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