After impressive performances in the Magners League and European Cup in January, British and Irish Lion Halfpenny looked to have returned to the top of his game but this latest injury could be a huge blow to player and country.
Wales are already without Scarlets wing George North who starred on the International stage in November but do have the services of Shane Williams who returned to fitness a fortnight ago.
Wales host England in the opening game of this season's championship, kick off is at 7:45pm at the Millennium Stadium.