Martyn Thomas returns at full back, with Will Harries moving to the wing and Adam Hughes dropping to the bench. Pat Leach and Tom Riley start in the centre, with Ashley Smith and Matthew Watkins nursing minor injuries from last weekend's victory over Edinburgh. Aled Brew starts on the wing, whilst the half back partnership of Jason Tovey and Wayne Evans continue. Mike Petri and Mathew Jones complete the substitutes.
The Dragons defeated the Italians 36-5 in the first fixture between the sides at Rodney Parade earlier this season.
NEWPORT GWENT DRAGONS SQUAD FOR AIRONI
Martyn Thomas, Will Harries, Tom Riley, Pat Leach, Aled Brew, Jason Tovey, Wayne Evans; Phil Price, Lloyd Burns, Dan Way, Rob Sidoli, Luke Charteris, Lewis Evans, Joe Bearman, Andrew Coombs.
Replacements: Steve Jones, Hugh Gustafson, Ben Castle, Scott Morgan, Hugo Ellis, Mike Petri, Mathew Jones, Adam Hughes.