In the backs, the only player keeping his place is Brendan Williams, while Ludovico Nitoglia and Tommaso Benvenuti are respectively winger and outside centre.
Alberto Sgarbi will be the inside centre, and Kristopher Burton and Tobias Botes are back, with their creative play, as fly-half and scrum-half.
The new RaboDirect PRO12 Ambassador, Paul Derbyshire, gives place to Gonzalo Padrò, who will be in the back row with Alessandro Zanni and Robert Barbieri.
The locks Corniel Van Zyl and Antonio Pavanello are confirmed again, while the front row has completely changed: the props Lorenzo Cittadini and Michele Rizzo will play with Franco Sbaraglini, who replaces injured Enrico Ceccato.
The match will be on live streaming at http://raisport.rai.it and will be broadcast recorded on Rai Sport 2 at 16:10.
Starting line-up:
15 Luke McLean
14 Ludovico Nitoglia
13 Tommaso Benvenuti
12 Alberto Sgarbi
11 Brendan Williams
10 Kristopher Burton
9 Tobias Botes
8 Robert Barbieri
7 Alessandro Zanni
6 Gonzalo Padrò
5 Corniel Van Zyl
4 Antonio Pavanello (captain)
3 Lorenzo Cittadini
2 Franco Sbaraglini
1 Michele Rizzo
On the bench:
16 Diego Vidal
17 Ignacio Fernandez Rouyet
18 Pedro Di Santo
19 Valerio Bernabò
20 Manoa Vosawai
21 Simon Picone
22 Edoardo Gori
23 Alberto Di Bernardo