In the forwards, Euan Murray replaces Moray Low at tighthead and Andrew Wilson replaces James Eddie at blindside flanker.
Warriors Head Coach Sean Lineen said: "Playing two Scottish teams in a row is slightly unusual for us but not having a major break over the festive period has meant that the team has stayed mentally focussed, which is very important. This will be our hardest game in December as the Border Reivers are a really good side and always go out to play attractive rugby.
"This game is so important to both sides as it could really turn Borders' season around for them. They'll have gained confidence from their away match against Biarritz and have had a chance to rest players with their free week in the Magners League but we'll be going there to do our best and hopefully the Glasgow supporters will make the journey to Netherdale to cheer us on and create a great atmosphere for the last match of the year."
15 Rory Lamont
14 Hefin O'Hare
13 Andy Henderson
12 Scott Barrow
11 Thom Evans
10 Dan Parks
9 Graeme Beveridge
1 Justin Va'a
2 Scott Lawson*
3 Euan Murray*
4 Dan Turner
5 Alastair Kellock* (Captain)
6 Andrew Wilson *
7 John Barclay*
8 Jon Petrie
Substitutes
16 Fergus Thomson*
17 Kevin Tkachuk
18 Andy Newman
19 James Eddie
20 Sam Pinder
21 Colin Gregor
22 Sean Marsden
Unavailable for selection due to illness/injury:
Johnnie Beattie* (ankle), Willie Brown** (jaw), Francisco Leonelli (hip/groin), Donnie Macfadyen (thigh), Graeme Morrison (groin), Mike Roberts (jaw).
* Member of the Scottish Institute of Sport. ** Member of the West of Scotland Institute of Sport.