The changes see Gunners' captain Chris Paterson return on the right wing while Phil Godman moves from stand-off to outside centre for Marcus Di Rollo. Matt Dey, who has today re-signed for a further two years [see below], fills the inside centre berth in place of Peter Jorgensen as Duncan Hodge takes the play maker role at No 10.
In the front row, Dave Hewett returns for Allan Jacobsen with Andrew Kelly rotating in to the hooker slot for Dougie Hall. A complete change in the back row sees Allister Hogg switch from open to blind side flanker while Simon Taylor returns in place of Dave Callam and Alan MacDonald starts at No 7.
Blackadder said: "Francisco Leonelli was unavailable due to a sore back but we've rotated a few players and given some others an opportunity. As far as I'm concerned it's an opportunity for the whole team - the last performance just wasn't us.
"Destiny is still in our hands. We're in fourth at the moment and there are six more games so we've got to go for it. I'm going to take the focus away from winning the league at the moment - the priority is to go out and play well," he added.
Edinburgh Gunners team:15 Hugo Southwell; 14 Chris Paterson CAPTAIN, 13 Phil Godman, 12 Matt Dey, 11 Simon Webster; 10 Duncan Hodge, 9 Mike Blair, 1 Dave Hewett, 2 Andrew Kelly, 3 Craig Smith; 4 Alastair Kellock, 5 Scott Murray, 6 Allister Hogg, 8 Simon Taylor, 7 Alan MacDonald
Substitutes:16 Dougie Hall, 17 Alasdair Dickinson, 18 Dave Duley, 19 Simon Cross, 20 Rory Lawson, 21 Peter Jorgensen, 22 Marcus Di Rollo